![]() ![]() Ohwoavworhua, F.O., Adelakun, T.A., and Kunle, O. Starch and Microcrystalline Cellulose: A New Coprocessed Excipient for Direct Compression, Pharm Sci Tech, Vol 5 (2). Limwong, V., Sutanthavibul, N., and Kulvanich, P., 2004, Spherical Composite Particles of Rice K., 1994, Teori dan Praktek Farmasi Industri II, Indonesia University Press, Jakarta. Lactose and Maize Starch for Tablet Formulation, Pharm Sci Tech, Vol 6, (2) M., 2004, Evaluation of New Coprocessed Compound Based on A Review of Co-processed Directly Compressible Excipients. Lactose-starch using factorial design, Indian J Pharm Sci, Vol 65 (1), 31-38 ![]() Investigation of direct compression characteristics of coprocessed ![]() Jenderal Pengawasan Obat dan Makanan Departemen Kesehatan Republik Indonesia. Farmakope Indonesia Edisi IV, Jakarta, Direktorat E., 2002, Pharmaceutics The Science of Dosage Form Design, Churcill Livingstone, New York.ĭepartemen Kesehatan Republik Indonesia, 1995. C., 2005, Pengantar Bentuk Sediaan Farmasi Edisi Keempat. Key words: cassava starch, Avicel PH 101, co-process, direct compression tabletĪnsel, H. The best compression properties of cassava starch-Avicel PH 101 co-process were crushing strength about 4,97☐,23 kp and friability about 0,52☐,03.% with disintegration time and tablet uniformity fulfill with requirement of pharmacopoeia. The best of mechanical-physical properties were flowability about 6,70☐,28 g/dt and tapping index about 12,57☑,18.%. The results indicated that ratio cassava starch-Avicel PH 101 (60:40) provided co-process with the best of mechanical-physical and compression properties. ![]() To achieve this goal, the thing that has been done are : (1) isolation of cassava starch (2) co-processing of cassava starch-Avicel PH 101 (3) testing of mechanic-physic properties of co-process of cassava starch-Avicel PH 101 (4) evaluation of co-process of cassava starch-Avicel PH 101 as diluent of direct compression tablet. The purpose of this research was to develop co-process of cassava starch-Avicel PH 101 for diluent of direct compression tablet. Cassava starch is tablet excipient with poor of both flowability and compressibility which can not be used as diluent of direct tablet compression. ![]()
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